The Powerful Hair Growing Ability Of Asia Sari Radix

In a 2005 study from the Journal of Dermatological Science, scientists examined the effects of 45 plant extracts that have been traditionally used for treating hair loss in individuals in order to identify potential hair growth stimulants. Asia sari radix is the root of the Asiasarum plant; Saishin in Japanese. If looking to prevent hair loss or thinning hair, Asia sari radix extract has shown the most promise in stopping hair loss of all the plant extracts examined.

The examination of the Asia sari radix extract was performed by using six-week-old female C57BL/6 and C3H mice. For 30 and 45 days, a topical application was applied to the backs of the mice. This was done by rubbing a 1% solution of Asia sari radix extract in a 40% ethanol solution onto the backs of the mice. Using cultured murine vibrissae follicles, protein synthesis was measured by the cysteine uptake assay. In addition, proliferation of the immortalized human keratinocyte cell line, also called HaCaT, and human dermal papilla (DP) cells were evaluated by the MTT and thymidine assays; the proliferation cells increased by 106.5% and 115%. Basically, this means that the Asia sari radix extract increased the number of cells that are greatly involved in producing hair. The mRNA levels of many growth factors that have been implicated in promoting hair growth were measured by reverse transcription-polymerase chain reaction.

As a result, among the plant extracts that were tested, the Asia sari radix extract provided the strongest hair growth stimulation in the C57BL/6 and C3H mice experiments. The extract of this plant greatly increased the protein synthesis in the vibrissae follicle cultures and the proliferation of the HaCaT and the human DP cells which were cultures in vitro. In addition to cell increases, vascular endothelial growth factor expression was also increased by the application of the Asia sari radix extract. VEGF plays a very important role in the angiogenesis process, which is the growth of new blood vessels from pre-existing vessels. VEGF expression is also typically higher in the anagen growth phase and lower during the catagen (shedding) and telogen (resting) growth phases. It has not been determined whether VEGF directly affects hair growth or not, however; it has been suggested that VEGF can affect hair by regulating the expression of VEGF.

These results suggest that the Asia sari radix plant extract has strong hair growth promoting potential. This conclusion may be due to the fact that its regulatory effects on both cell growth and growth factor gene expression. A possible explanation for the observed results is that the extract increased the uptake of the amino acid cysteine, which has been directly correlated with hair follicle growth. Now, there is a product available that contains a pure mixture of Asia sari radix called Aradix. This is placed in pure mineral oil, because mineral oil is the fastest way to permit the oil to penetrate the scalp, thus promoting hair growth.

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